Gene Modified Human T Cells Tetramer Binding but Not the Function of TCR Gene Transfer: TCR Variants Improve Targeting the Wilms Tumor Antigen 1 by
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منابع مشابه
Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells.
We have previously described the functional activity of a human TCR specific for an HLA-A2-presented peptide derived from the Wilms tumor Ag 1 (WT1). Recent studies showed that the expression and function of human TCR was improved by the introduction of an additional disulfide bond between the alpha- and beta-chains or by the exchange of the human constant region for murine sequences. In this s...
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تاریخ انتشار 2007